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人才隊伍

全體研究組長

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李飛

博士

代謝重塑與細胞命運決定研究組組長

郵箱: fei.li@sinh.ac.cn

電話: +86-21-54923285

所屬部門: 腫瘤與微環(huán)境重點實驗室

個人簡歷

2025.01－至　今：中國科學院上海營養(yǎng)與健康研究所研究員
2021.06－2024.12：中國科學院分子細胞科學卓越創(chuàng)新中心博士后/副研究員
2016.09－2021.06：中國科學院分子細胞科學卓越創(chuàng)新中心博士
2012.09－2016.06：西北農(nóng)林科技大學學士

研究方向

代謝重塑與細胞命運決定

研究內容

聚焦“代謝重塑與腫瘤生物學”的基礎和臨床科學問題，結合單細胞多組學、類器官培養(yǎng)、高通量篩選和基因編輯譜系示蹤小鼠等傳統(tǒng)和新興實驗技術手段，從代謝和免疫的整合生物學角度解析腫瘤細胞和腫瘤微環(huán)境細胞命運決定的調控機制，開發(fā)新型腫瘤防治策略。主要研究方向包括：（1）內源激素代謝平衡與腫瘤免疫調控；（2）外源營養(yǎng)代謝干預與腫瘤精準防治。

代表論著（#第一作者，*通訊作者）

Li F^#, Dai PF^#, Shi HL^#, Zhang YJ^#, He J, Gopalan A, Li D, Chen Y, Du YR, Xu GL, Yang WW*, Liang C*, Gao D*. LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer. Cell Research 2025 In press.
Li F^#, Xing XD^#, Jin QQ^#, Wang XM^#, Dai PF^#, Han M^#, Shi HL, Zhang Z, Shao XL, Peng YY, Zhu YQ, Xu JY, Li D, Chen Y, Wu W, Wang Q, Yu C*, Chen L*, Bai F*, Gao D*. Sex differences orchestrated by androgens at single-cell resolution. Nature 2024 May;629(8010):193-200.
Li X^#, Li F^#, Ye F^#, Guo HT, Chen WT, Jin J, Wang YR, Dai PF, Shi HL, Tao HR, Dang WZ, Ding YL, Wang MC, Jiang HL, Chen KX, Zhang NX, Gao D*, Zhang YY*, Luo C*. Spermine Is a Natural Suppressor of AR Signaling in Castration-Resistant Prostate Cancer. Cell Reports 2023 Jul 25;42(7):112798.
Han M^#, Li F^#*, Zhang YH^#, Dai PF, He J, Li YG, Zhu YQ, Zheng JK, Huang H, Bai F, Gao D*. FOXA2 drives lineage plasticity and Kit pathway activation in neuroendocrine prostate cancer. Cancer Cell 2022 Nov 14;40(11):1306-1323.
Peng JY^#, Li F^#, Wang J, Wang CX, Jiang YA, He J, Yuan K, Bei JX, Wang V, Zhou B, Chen LN, Gao D*, Zhao Y*. Identification of a rare Gli1+ progenitor cell population contributing to liver regeneration during chronic injury. Cell Discovery 2022 Nov 1;8(1):118.
Li F^#, Han M^#, Dai PF^#, Xu W^#, He J^#, Tao XT^#, Wu Y^#, Tong XY, Xia XY, Guo WX, Zhou YJ, Li YG, Zhu YQ, Zhang XY, Liu Z, Aji R, Cai X, Li YT, Qu D, Chen Y, Jiang SB, Wang Q, Ji HB, Xie YH*, Sun YH*, Lu L*, Gao D*. Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide. Nature Communications 2021 Feb 8;12(1):866.
Li F^#, Yuan QY^#, Di W^#, Xia XY^#, Liu Z, Mao NH, Li L, Li CF, He J, Li YG, Guo WX, Zhang XY, Zhu YQ, Aji R, Wang SQ, Chi P, Carver B, Wang Y*, Chen Y*, Gao D*. ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming. Journal of Clinical Investigation 2020 Nov 2;130(11):5924-5941.
Tang J^#, Wang HX^#, Huang XZ^#, Li F^#, Zhu H, Li Y, He LJ, Zhang H, Pu WJ, Liu K, Zhao H, Bentzon JF, Yu Y, Ji Y, Nie Y, Zhang L*, Gao D*, Zhou B*. Sca1+ Vascular Stem Cells Contribute to Smooth Muscle for Artery Repair and Regeneration. Cell Stem Cell 2020 Jan 2;26(1):81-96.