郵箱: lylong@sinh.ac.cn
電話: +86-21-54920721
所屬部門: 腫瘤與微環(huán)境重點(diǎn)實驗室
2022.09-至 ?今：中國科學(xué)院上海營養(yǎng)與健康研究所 研究員
2022.01-2022.08：St. Jude Children's Research Hospital 資深科學(xué)家
2014.12-2022.01：St. Jude Children's Research Hospital 博士后
2013.08-2014.07：中國科學(xué)院上海生命科學(xué)研究院營養(yǎng)科學(xué)研究所 研究助理
2006.09-2013.07：中國科學(xué)院上海生命科學(xué)研究院 博士
2002.09-2006.06：武漢大學(xué)生命科學(xué)學(xué)院 學(xué)士
T細(xì)胞分化和功能調(diào)控
綜合應(yīng)用CRISPR篩選、單細(xì)胞RNA測序等系統(tǒng)生物學(xué)手段和常規(guī)生物化學(xué)方法，結(jié)合小鼠疾病模型和臨床病人樣品來研究T細(xì)胞的分化和功能在腫瘤、自身免疫性疾病、過敏性炎癥和代謝性疾病（例如糖尿?。┑炔±項l件下如何被精細(xì)調(diào)控；并據(jù)此開發(fā)新的治療靶點(diǎn)和疾病干預(yù)策略。
1.?Liu Z., Zhang Y., Ma N., Yang Y., Ma Y., Wang F., Wang Y., Wei J., Chen H., Tartarone A., Velotta J. B., Dayyani F., Gabriel E., Wakefield C. J., Kidane B., Carbonelli C., Long L.*, Liu Z.*, Su J.*, Li Z*. (2023) Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma. Cancer Cell 41 (11), 1852-1870. e9 (* co-corresponding author)
2.?Xia J., Ma N., Shi Q., Liu Q. C., Zhang W., Cao H. J., Wang Y. K., Zheng Q. W., Ni Q. J., Xu S., Zhu B., Qiu X. S., Ding K., Huang J. Y., Liang X., Chen Y., Xiang Y. J., Zhang X. R., Qiu L., Chen W., Xie D., Wang X., Long L.*, Li J. J*. (2023) XAF1 promotes colorectal cancer metastasis via VCP–RNF114–JUP axis. Journal of Cell Biology 223 (2), e202303015 (* co-corresponding author)
3.?Long L.#, Wei J., Lim S. A., Raynor J. L., Shi H., Connelly J. P., Wang H., Guy C., Xie B., Chapman N. M., Fu G., Wang Y., Huang H., Su W., Saravia J., Risch I., Wang Y. D., Li Y., Niu M., Dhungana, Y., Kc, A., Zhou, P., Vogel, P., Yu, J., Pruett-Miller, S. M., Peng, J., Chi, H*. (2021) CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity. Nature 600,308-313
4.?Wei, J.#, Long, L.#, Zheng W., Dhungana, Y., Lim, S. A., Guy, C., Wang, Y., Wang, Y., Qian, C., Xu, B., Kc, A., Saravia, J., Huang, H., Yu, J., Doench, J. G., Geiger, T. L., Chi, H*. (2019) Targeting Regnase-1 programs long-lived effector T cells for cancer therapy. Nature 576(7787):471-476 (# co-first author)
5.?Long, L.#, Deng, Y., Yao, F., Guan, D., Feng, Y., Jiang, H., Li, X., Hu, P., Lu, X., Wang, H., Li, J., Gao, X., Xie, D*. (2014) Recruitment of phosphatase PP2A by RACK1 adaptor protein deactivates transcription factor IRF3 and limits type I interferon signaling. Immunity 40:515-529
6.?Huang, H., Zhou, P., Wei, J., Long, L., Shi, H., Dhungana, Y., Chapman, N. M., Fu, G., Saravia, J., Raynor, J. L., Liu, S., Palacios, G., Wang, Y. D., Qian, C., Yu, J., Chi, H*. (2021) In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8(+) T cell fate decisions. Cell 2021 Mar 4;184(5):1245-1261.e21
7.?Fu, G., Guy, C. S., Chapman, N. M., Palacios, G., Wei, J., Zhou, P., Long, L., Wang, Y. D., Qian, C., Dhungana, Y., Huang, H., Kc, A., Shi, H., Rankin, S., Brown, S. A., Johnson, A., Wakefield, R., Robinson, C. G., Liu, X., Sheyn, A., Yu, J., Jackowski, S., Chi, H*. (2021) Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine. Nature 2021 Jul;595(7869):724-729
8.?Lim, S. A., Wei, J., Nguyen, T. M., Shi, H., Su, W., Palacios, G., Dhungana, Y., Chapman, N. M., Long, L., Saravia, J., Vogel, P., Chi, H*. (2021) Lipid signalling enforces functional specialization of Treg cells in tumours. Nature 2021 Mar;591(7849):306-311
9.?Zheng, W., Wei, J., Zebley, C., Jones, Long, L., Dhungana, Y., Wang, Y. D., Mavuluri, J., Long, L., Fan, Y., Youngblood, B., Chi, H., Geiger, T. L*. (2021) Regnase-1 suppresses TCF-1+ precursor exhausted T cell formation to limit CAR T cell responses against ALL. Blood 138(2):122-135.
10.?Su, W., Chapman, N. M., Wei, J., Zeng, H., Dhungana, Y., Shi, H., Saravia, J., Zhou, P., Long, L., Rankin, S., Kc, A., Vogel, P., Chi, H*. (2020) Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells. Cell Metab 2020 Dec 1;32(6):996-1011.e7
11.?Huang, H., Long, L., Zhou, P., Chapman, N. M., Chi, H*. (2020) mTOR signaling at the crossroads of environmental signals and T-cell fate decisions. Immunol Rev 2020 May;295(1):15-38
12.?Shi, H., Chapman, N. M., Wen, J., Guy, C., Long, L., Dhungana, Y., Rankin, S., Pelletier, S., Vogel, P., Wang, H., Peng, J., Guan, K. L., Chi, H*. (2019) Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity 2019 Dec 17;51(6):1012-1027.e7
13.?Wang, Y., Du, X., Wei, J., Long, L., Tan, H., Guy, C., Dhungana, Y., Qian, C., Neale, G., Fu, Y. X., Yu, J., Peng, J., Chi, H*. (2019) LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity. Cell Res 2019 May;29(5):391-405
14.?Yang, K., Blanco, D. B., Neale, G., Vogel, P., Avila, J., Clish, C. B., Wu, C., Shrestha, S., Rankin, S., Long, L., Kc, A., Chi, H*. (2017) Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling. Nature 548, 602-606
15.?Karmaus, P. W. F., Herrada, A. A., Guy, C., Neale, G., Dhungana, Y., Long, L., Vogel, P., Avila, J., Clish, C. B., Chi, H*. (2017) Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis. J Exp Med 214, 2629-2647
16.?Li, J. J., Sun, Z. J., Yuan, Y. M., Yin, F. F., Bian, Y. G., Long, L. Y., Zhang, X. L., Xie, D. (2017) EphB3 Stimulates Cell Migration and Metastasis in a Kinase-dependent Manner through Vav2-Rho GTPase Axis in Papillary Thyroid Cancer. J Biol Chem 292, 1112-1121
17.?Wei, J., Long, L., Yang, K., Guy, C., Shrestha, S., Chen, Z., Wu, C., Vogel, P., Neale, G., Green, D. R., Chi, H*. (2016) Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis. Nat Immunol 17, 277-285
18.?Bao, W. D., Fan, Y., Deng, Y. Z., Long, L. Y., Wang, J. J., Guan, D. X., Qian, Z. Y., An, P., Feng, Y. Y., He, Z. Y., Wang, X. F., Phillip Koeffler, H., Hu, R., Wang, J., Wang, X., Wang, F., Li, J. J., Xie, D*. (2016) Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis. J Hepatol 65, 137-145
19.?Guan, D. X., Shi, J., Zhang, Y., Zhao, J. S., Long, L. Y., Chen, T. W., Zhang, E. B., Feng, Y. Y., Bao, W. D., Deng, Y. Z., Qiu, L., Zhang, X. L., Koeffler, H. P., Cheng, S. Q., Li, J. J., Xie, D*. (2015) Sorafenib enriches epithelial cell adhesion molecule-positive tumor initiating cells and exacerbates a subtype of hepatocellular carcinoma through TSC2-AKT cascade. Hepatology 62, 1791-1803
20.?Yao, F., Long, L. Y., Deng, Y. Z., Feng, Y. Y., Ying, G. Y., Bao, W. D., Li, G., Guan, D. X., Zhu, Y. Q., Li, J. J., Xie, D*. (2014) RACK1 modulates NF-kappaB activation by interfering with the interaction between TRAF2 and the IKK complex. Cell Res 24, 359-371
21.?Deng, Y. Z., Yao, F., Li, J. J., Mao, Z. F., Hu, P. T., Long, L. Y., Li, G., Ji, X. D., Shi, S., Guan, D. X., Feng, Y. Y., Cui, L., Li, D. S., Liu, Y., Du, X., Guo, M. Z., Xu, L. Y., Li, E. M., Wang, H. Y., Xie, D*. (2012) RACK1 suppresses gastric tumorigenesis by stabilizing the beta-catenin destruction complex. Gastroenterology 142, 812-823 e815
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