| Decreased GATA3 levels cause changed mouse cutaneous innate lymphoid cell fate, facilitating hair follicle recycling | |
| 論文作者 | Ren, GQ; Zhang, YM; Liu, JM; Cheng, WW; Wu, D; Han, MW; Zeng, YY; Zhao, XY; Hu, LN; Zeng, M; Gurram, RK; Hu, XL; Zhou, B; Hou, ZY; Zhu, JF; Jin, WF; Zhong, C |
| 期刊/會議名稱 | DEVELOPMENTAL CELL |
| 論文年度 | 2024 |
| 論文類別 | |
| 摘要 | In mice, skin-resident type 2 innate lymphoid cells (ILC2s) exhibit some ILC3-like characteristics. However, the underlying mechanism remains elusive. Here, we observed lower expression of the ILC2 master regulator GATA3 specifically in cutaneous ILC2s (cILC2s) compared with canonical ILC2s, in line with its functionally divergent role in transcriptional control in cILC2s. Decreased levels of GATA3 enabled the expansion of RORyt fate-mapped (RORytfm+) fm+ ) cILC2s after postnatal days, displaying certain similarities to ILC3s. Single-cell trajectory analysis showed a sequential promotion of the RORytfm+ fm+ cILC2 divergency by RORyt and GATA3. Notably, during hair follicle recycling, these RORytfm+ fm+ cILC2s accumulated around the hair follicle dermal papilla (DP) region to facilitate the process. Mechanistically, we found that GATA3-mediated integrin oc3R1 upregulation on RORytfm+ fm+ cILC2s was required for their positioning around the DP. Overall, our study demonstrates a distinct regulatory role of GATA3 in cILC2s, particularly in promoting the divergence of RORytfm+ fm+ cILC2s to facilitate hair follicle recycling. |
| 期 | 14 |
| 卷 | 59 |
| 影響因子 | 10.7 |
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