| CyclicPepedia: a knowledge base of natural and synthetic cyclic peptides | |
| 論文作者 | Liu, L; Yang, L; Cao, SQ; Gao, ZG; Yang, B; Zhang, GQ; Zhu, RX; Wu, DF |
| 期刊/會議名稱 | BRIEFINGS IN BIOINFORMATICS |
| 論文年度 | 2024 |
| 論文類別 | |
| 摘要 | Cyclic peptides offer a range of notable advantages, including potent antibacterial properties, high binding affinity and specificity to target molecules, and minimal toxicity, making them highly promising candidates for drug development. However, a comprehensive database that consolidates both synthetically derived and naturally occurring cyclic peptides is conspicuously absent. To address this void, we introduce CyclicPepedia (https://www.biosino.org/iMAC/cyclicpepedia/), a pioneering database that encompasses 8744 known cyclic peptides. This repository, structured as a composite knowledge network, offers a wealth of information encompassing various aspects of cyclic peptides, such as cyclic peptides' sources, categorizations, structural characteristics, pharmacokinetic profiles, physicochemical properties, patented drug applications, and a collection of crucial publications. Supported by a user-friendly knowledge retrieval system and calculation tools specifically designed for cyclic peptides, CyclicPepedia will be able to facilitate advancements in cyclic peptide drug development. |
| 期 | 3 |
| 卷 | 25 |
| 影響因子 | 6.8 |
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